Endocrine Abstracts

Annexin 1 (ANXA1, lipocortin 1), a Ca2+ and phospholipid binding protein, is a strong candidate mediator of the interplay between the immune and neuroendocrine systems. Within the neuroendocrine system ANXA1 is expressed in abundance by the non-secretory pituitary folliculo-stellate (FS) cells (1), which show characteristics of resident microglia. We have previously reported that IL-6 up-regulates ANXA1 expression in the liver in vivo and in A549 cells (lung epithelial...

Acknowledgements: This work was generously supported by the Wellcome TrustAnnexin 1 (ANXA1) plays an important role in mediating the negative feedback effects of glucocorticoids on the HPA axis. It is released from non-secretory folliculostellate (FS) cells by glucocorticoids and acts locally to suppress ACTH release from corticotrophs. Previous studies suggest that the steroid-induced translocation of ANXA1 across the FS cell membrane is effected via me...

Annexin 1 (ANXA1) plays an important role in mediating the negative feedback effects of glucocorticoids on the HPA axis. In the anterior pituitary gland ANXA1 is localised mainly to the non-secretory folliculostellate (FS) cells. It is released from these cells by glucocorticoids and acts locally to suppress ACTH release from corticotrophs. Functional and histological studies suggest that the steroid-induced translocation of ANXA1 across the FS cell membrane is effected via me...

The anti-inflammatory actions of glucocorticoids are mediated in part by inhibition of nuclear factor kappa B (NFkappaB) activation. Reports that NFkappaB activation within anterior pituitary folliculo-stellate (FS) cells provokes the release of interleukin-6 (IL-6) [1] which acts a paracrine mediator of ACTH release [2], raise the possibility that NFkappaB is a potential target for the negative feedback actions of glucocorticoids upon the hypothalamo-pitu...

The formylated peptide receptors comprise a polymorphic family of seven transmembrane domain Gi-protein-coupled receptors. Three family members have been characterised in man (FPR, FPRL1 and FPRL2) and eight in mice (Fpr1, Fpr-rs1 to Fpr-rs7) (1). FPR was originally identified as a receptor for formylated bacterial peptides but recent studies suggest that it is also a target for annexin 1 (ANXA1) (2), a protein mediator of glucocorticoid action in the neuroendocrine system (3)...

Annexin 1 (ANXA1) is a Ca 2+ and phospholipid binding protein that plays an important role as a mediator of glucocorticoid (GC) action in the host-defence and neuroendocrine-systems. Our previous studies (Christian et al., 1998) in ovarietomised rats +/- oestradiol (E2) replacement suggested oestrogen may exert an inhibitory influence on ANXA1 expression in the pituitary gland. Our more recent finding that ANXA1 knockout mice exhibit unexpected sexual dimorphisms in...

Annexin 1 (ANXA1) belongs to a well-conserved superfamily of structurally-related Ca2+ and phospholipid-binding proteins. We first described its induction and role as a mediator of glucocorticoid (GC) actions within the host defence and neuroendocrine systems. In addition we provided evidence that an extracellular pool of ANXA1 is responsible for many of the regulatory actions of the protein, particularly in the pituitary gland where ANXA1 exported from folliculoste...

Annexin 1 (ANXA1), a Ca2+ and phospholipid binding protein, is an important mediator of glucocorticoid (GC) action in the host defence and neuroendocrine systems (1). It is not however known whether the dysregulation of the inflammatory response sometimes observed in patients with disturbances in GC secretion is associated with alterations in PBL ANXA1 expression/activity. To address this question we have (a) examined ANXA1 expression (flow cytometry and western blot analysis)...